shuttle pharmaceuticals ipo
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Shuttle pharmaceuticals ipo

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Shuttle Pharma holds the exclusive rights for development of this drug platform. Lead inventor Scott Grindrod , PhD describes histone deacetylase HDAC inhibitors as a novel class of drugs targeting enzymes involved in regulation of gene expression. HDACs regulate gene expression by changing the conformation of chromatin in cells into a tightly coiled and transcriptionally inactive form.

However, acetylated chromatin is more open and supports transcription. Inhibitors of HDAC enzymes can inhibit cell growth, regulate tubulin stability, turn on transcription of tumor suppressor genes, and activate cellular immunity.

These are key target functions for cancer treatment. Ataxia-telangiectasia is a human genetic disease characterized by extreme radiation sensitivity, neurological immune impairment, and premature aging. In normal cells, ATM protein activation enables efficient repair of radiation damage to protect the genome and promote cell survival. There are 12 HDAC enzymes with important functions for maintaining health. Clinical applications of pan-HDAC inhibitors have been limited by off target toxicities.

According to Dr. Anatoly Dritschilo , Shuttle Pharma's CEO, the interest in immunotherapy to treat cancers in combination with other modalities has focused particular attention on HDAC6 selective inhibitors. Shuttle Pharmaceuticals, Inc. Currently, achieving better dose distributions within the tumor volume has reached a plateau and further improvements resulting in cancer cures need to take advantage of biological modifications to sensitize cancer cells, protect normal tissues, and stimulate the immune system.

Drugs that show sensitizing properties offer a solution to this problem. In June , Shuttle Pharmaceuticals, Inc. About us. Pursuing a Cure for Cancer. We Believe.

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Shuttle Pharmaceuticals. Shuttle Pharmaceuticals Overview Update this profile. Founded Status Private. Employees Latest Deal Type Seed. Shuttle Pharmaceuticals General Information Description Operator of a pharmaceutical company intended to improve the safety, efficacy and quality of life of cancer patients undergoing radiation therapy. Formerly Known As. Shuttle Pharma Acquisition. Ownership Status. Privately Held backing. Financing Status. Venture Capital-Backed.

Primary Industry. Other Industries. Primary Office. Shuttle Pharmaceuticals Timeline Financing Round. What you see here scratches the surface Request a free trial. Want to dig into this profile? Shuttle Pharmaceuticals Patents. Shuttle Pharmaceuticals Recent Patent Activity.

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Shuttle Pharmaceuticals Inc. plans to offer million common shares in its IPO at a price of $8 per share. Shuttle Pharmaceuticals - intends to apply to have shares of common stock listed on nyse market. The company, which aims to trade under the ticker "SHPH" on the Nasdaq exchange, plans to offer anywhere from million to million shares.